Effectiveness of Anti-HIV Drugs in Patients Who Have Not Received Previous Anti-HIV Drugs During Different Stages of HIV Infection
Completed · Not applicable
Conditions studied: HIV Infections
In brief
The purpose of this study is to compare changes in HIV levels and certain immune cells among patients at different stages of HIV infection. This study will also see how a combination of stavudine (d4T), lamivudine (3TC), indinavir (IDV), and nelfinavir (NFV) affects these levels. Current findings in anti-HIV drug treatment have led to a greater understanding of the background of HIV. To find the best anti-HIV treatment to eliminate all HIV viruses, cells and tissues infected with the HIV virus are examined after combination anti-HIV treatment, when the level of HIV infection is low. The ERADICATE study will examine the idea that HIV viruses can be eliminated at any stage of infection over time.
Key facts
- Study ID
- NCT00006443
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 24
- Last updated by the study team
- 2011-03-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients may be eligible for this study if they:
- Are infected with HIV and have had certain tests to indicate the stage of their disease.
- Are at least 18 years old.
- Practice birth control during the study.
You may not qualify if…
- Patients will not be eligible for this study if they:
- Have received anti-HIV medication for more than 1 week.
- Have a serious AIDS-related infection or other illness.
- Require medication that interferes with the study drugs.
- Have had a peripheral neuropathy, a painful condition affecting the nervous system.
- Have been given drugs that affect the immune system within 2 weeks before study entry.
- Have a bleeding disorder including hemophilia.
- Abuse alcohol or substances.
- Are pregnant or breast-feeding.
Where it is running
- Michael S. Saag — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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