Study of Plexiform Neurofibromas in Neurofibromatosis Type 1

Completed

Conditions studied: Plexiform Neurofibromas, NF1

In brief

Background: -Plexiform neurofibromas in patients with NF1 are a significant cause of morbidity but little is known about the natural history of these lesions. Objectives: * The purpose of this study is to monitor the natural history of plexiform neurofibromas and to evaluate the usefulness of volumetric MRI tumor measurements in this disease. * Other goals of the study are to provide a body of normative data on the growth rate of plexiform neurofibromas and to establish a tissue repository and pathology review center to allow future studies of the pathogenesis of neurofibromas and clinical trials of potential therapeutic agents. Design \- This study is coordinated by Dr. Bruce Korf, and was initiated when he was at the Partners Center for Human Genetics, Boston, MA.

Key facts

Study ID
NCT00006435
Run by
National Cancer Institute (NCI)
People needed
24
Starts
2001-05-18
Expected to finish
2020-05-01
Last updated by the study team
2020-05-04

Who can join

Age: any, up to 100. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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