Alemtuzumab Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Lymphocytic Leukemia

Completed · Phase 2

Conditions studied: Leukemia

In brief

RATIONALE: Monoclonal antibodies such as alemtuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy. Combining monoclonal antibody therapy, chemotherapy, radiation therapy, and peripheral stem cell transplantation may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of alemtuzumab plus peripheral stem cell transplantation in treating patients who have chronic lymphocytic leukemia.

Key facts

Study ID

NCT00006390

Run by

Eastern Cooperative Oncology Group

Starts

2001-07-05

Last updated by the study team

2023-06-22

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Veterans Affairs Medical Center - Lakeside Chicago — Chicago, Illinois, United States
• Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States
• Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
• Cancer Center at Tufts - New England Medical Center — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• CCOP - Metro-Minnesota — Saint Louis Park, Minnesota, United States
• CCOP - Northern New Jersey — Hackensack, New Jersey, United States
• CCOP - Geisinger Clinic and Medical Center — Danville, Pennsylvania, United States
• Penn State Cancer Institute at Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
• Abramson Cancer Center at the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
• Hillman Cancer Center at University of Pittsburgh Cancer Institute — Pittsburgh, Pennsylvania, United States
• University of Wisconsin Comprehensive Cancer Center — Madison, Wisconsin, United States
• CCOP - Marshfield Clinic Research Foundation — Marshfield, Wisconsin, United States

Full record on ClinicalTrials.gov

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