Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer
Completed · Phase 3 · Has a placebo group
Conditions studied: Cognitive/Functional Effects, Delirium, Depression, Lung Cancer, Radiation Toxicity
In brief
RATIONALE: Donepezil and vitamin E may be able to decrease side effects caused by radiation therapy given to prevent brain metastases in patients with small cell lung cancer. It is not yet known if donepezil and vitamin E are effective in preventing side effects caused by radiation therapy to the head. PURPOSE: Randomized phase III trial to determine the effectiveness of donepezil and vitamin E in preventing side effects caused by radiation therapy given to prevent brain metastases in patients who have small cell lung cancer.
Key facts
- Study ID
- NCT00006349
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 9
- Starts
- 2001-02-01
- Expected to finish
- 2007-01-01
- Last updated by the study team
- 2016-07-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- CCOP - Scottsdale Oncology Program — Scottsdale, Arizona, United States
- Mayo Clinic — Jacksonville, Florida, United States
- CCOP - Illinois Oncology Research Association — Peoria, Illinois, United States
- CCOP - Carle Cancer Center — Urbana, Illinois, United States
- CCOP - Cedar Rapids Oncology Project — Cedar Rapids, Iowa, United States
- CCOP - Iowa Oncology Research Association — Des Moines, Iowa, United States
- Siouxland Hematology-Oncology — Sioux City, Iowa, United States
- CCOP - Wichita — Wichita, Kansas, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- CCOP - Missouri Valley Cancer Consortium — Omaha, Nebraska, United States
- Medcenter One Health System — Bismarck, North Dakota, United States
- CCOP - Merit Care Hospital — Fargo, North Dakota, United States
- Allegheny General Hospital — Pittsburgh, Pennsylvania, United States
- Rapid City Regional Hospital — Rapid City, South Dakota, United States
- CCOP - Sioux Community Cancer Consortium — Sioux Falls, South Dakota, United States
Full record on ClinicalTrials.gov
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