Immune Response to Hepatitis C Virus

Completed

Conditions studied: Hepatitis C

In brief

This study will identify and characterize immune factors involved in hepatitis C infection and elimination of the virus. Individual responses to hepatitis C infection vary; some people are able to eliminate the virus, whereas others remain chronically infected. This study may identify factors important in preventing infection that may be of help in developing a vaccine or more effective treatments. People over 18 years old who have been exposed to hepatitis C virus may participate in this study. Subjects will be recruited from the National Institutes of Health, Inova Fairfax Hospital, Occupational Medical Services-IDP P.C., Washington Hospital Center and Holy Cross Hospital, all in the Washington, D.C. metropolitan area. Individual patients from other centers will also be recruited on a case by case basis. Participants will have 40 to 60 cc (1 to 2 ounces) of blood drawn at seven intervals. The first collection will be as soon as possible after exposure to hepatitis C virus and then again at 2, 4, 6, 12, 24, and 48 weeks after exposure. The white blood cells will be studied for their response to the virus, and markers for infection will be followed. If infection develops, additional samples of blood may be requested, and patients will be offered evaluation for treatment. Test results will be kept confidential and will not be entered into any medical records.

Key facts

Study ID

NCT00006301

Run by

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

People needed

89

Starts

2000-09-24

Expected to finish

2015-03-24

Last updated by the study team

2019-12-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Subjects with a Hct of less than 30.

Where it is running

• Washington Hospital Center — Washington D.C., District of Columbia, United States
• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
• Holy Cross Hospital, Silver Spring — Silver Spring, Maryland, United States
• Occupational Medicine Services — Annandale, Virginia, United States
• INOVA Fairfax Hospital — Falls Church, Virginia, United States

Full record on ClinicalTrials.gov

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