Glucose Regulation During Risperidone and Olanzapine Treatment

Status unconfirmed · Not applicable

Conditions studied: Schizophrenia

In brief

The overall purpose of this research is to look at how two of the most commonly prescribed newer antipsychotic medications, risperidone and olanzapine, affect substances in the body such as glucose and insulin. Undesirable changes in blood sugar control, or glucose regulation, and type 2 diabetes can occur more commonly in individuals with schizophrenia compared to healthy subjects and subjects with other psychiatric conditions. While abnormalities in glucose regulation were first reported in schizophrenia before the introduction of antipsychotic medications, antipsychotic treatment may contribute significantly to abnormalities in glucose regulation. Attention to the way that antipsychotic medications may affect glucose regulation has increased as doctors have become more concerned in general about disease- and drug-related medical complications, including weight gain during antipsychotic treatment.

Key facts

Study ID

NCT00006195

Run by

National Center for Research Resources (NCRR)

Last updated by the study team

2006-10-12

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• meet DSM-IV criteria for schizophrenia, any type, or schizoaffective disorder;
• able to give informed consent;
• no medication changes for 2 weeks prior to and during the period of study;
• currently taking olanzapine, risperidone, haloperidol or another typical antipsychotic

Where it is running

• Washington University — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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