Cyclooxygenase Levels Following Surgery to Remove Third Molars (Wisdom Teeth)
Completed
Conditions studied: Healthy, Inflammation
In brief
This study will measure levels of an enzyme called cyclooxygenase in gum tissue following third molar (wisdom tooth) extraction. Cyclooxygenase is thought to contribute to pain that normally follows tissue injury or surgery. Healthy volunteers between 16 and 35 years of age who require removal of their third molars may be eligible for this study. Participants will receive an injection of a local anesthetic (lidocaine) in the mouth and a sedative (midazolam) through an arm vein before surgery. Before the tooth is removed, a small tissue sample (biopsy) will be collected from the gum tissue covering one of the lower third molars to be extracted. After surgery, a second biopsy will be taken at some point between just after surgery to the time when pain from the extraction starts to develop. These tissue samples will be analyzed for cyclooxygenase levels. Patients will stay in the clinic for up to 4 hours after surgery while the anesthetic wears off. During this time, they will complete pain questionnaires. If needed, patients may receive additional medicine for pain relief at any time during the surgery or the 4-hour observation period. They will also be given standard pain medication to take home at the end of the study.
Key facts
- Study ID
- NCT00006175
- Run by
- National Institute of Dental and Craniofacial Research (NIDCR)
- People needed
- 160
- Starts
- 2000-08-01
- Expected to finish
- 2005-10-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects will be healthy volunteers between the ages 16-35 years presenting to the Clinical Center for removal of their third molars.
- The type of third molar will be characterized at the time of screening by oral exam and panoramic radiograph:
- Erupted tooth: Clinical crown is present in the mouth and is not covered by soft tissue.
- Soft tissue impaction: Clinical crown is not present in the mouth but the adjacent alveolar bone does not cover any portion of the crown in the radiograph.
- Partial bony impaction: Clinical crown is not present in the mouth and the alveolar bone covers some but not all of the crown in the radiograph.
- Full bony impaction: Clinical crown is not present in the mouth and the alveolar bone covers most or all of the crown in the radiograph.
- Patients will be eligible for inclusion in this study if the two mandibular molars are classified as partial or full bony impactions.
You may not qualify if…
- Patients who are pregnant or nursing.
- Presence of infection or inflammation [pericoronitis] at either extraction site.
- Patients who are taking any of the following drugs: anti-depressants, diuretics, aspirin on a near daily basis, coumadin or other blood thinners; or other drugs that might influence pain report or COX formation, e.g. steroids.
Where it is running
- National Institute of Dental And Craniofacial Research (NIDCR) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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