Decompression Intervention of Variceal Rebleeding Trial (DIVERT)

Completed · Phase 3

Conditions studied: Esophageal and Gastric Varices, Liver Cirrhosis

In brief

The Decompression Intervention of Variceal Rebleeding Trial (DIVERT) is a multi-center prospective randomized clinical trial comparing the radiologic procedure of transjugular intrahepatic portal-systemic shunt (TIPS) with the surgical procedure of distal splenorenal shunt (DSRS) for variceal bleeding in patients with Child's Class A and B cirrhosis. This is recognized nationally and internationally as the study that will answer the question as to which of these is the best treatment for decompression of varices in patients who have failed endoscopic and pharmacologic therapy.

Key facts

Study ID: NCT00006161
Run by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
People needed: 140
Starts: 1996-12-01
Expected to finish: 2003-12-01
Last updated by the study team: 2010-01-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Variceal bleeding secondary to cirrhosis and portal hypertension
Child's Class A or B cirrhosis of any etiology
Patients who have failed endoscopic therapy (sclerotherapy or banding) of varices; or patients who are not candidates for endoscopic therapy

You may not qualify if…

Prior shunt procedure
Portal vein thrombosis
Polycystic liver disease
Intractable ascites
Prior organ transplant
Any medical intractable disease

Where it is running

University of Miami School of Medicine — Miami, Florida, United States
Emory University — Atlanta, Georgia, United States
Cleveland Clinic Foundation — Cleveland, Ohio, United States
University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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