Decompression Coring Versus Conservative Therapy in Patients With Avascular Necrosis of the Hip Related to Sickle Cell Disease

Completed · Not applicable

Conditions studied: Bone Avascular Necrosis, Sickle Cell Anemia

In brief

OBJECTIVES: I. Phase II trial to determine surgical morbidity of decompression coring, including any adverse events in the perioperative period and the rate of secondary medical or surgical interventions. II. Collect preliminary data to determine if decompression coring results in a substantial improvement in pain and mobility compared to conservative therapy in patients with avascular necrosis of the hip related to sickle cell disease.

Key facts

Study ID

NCT00006130

Run by

UCSF Benioff Children's Hospital Oakland

People needed

50

Starts

1999-06-01

Last updated by the study team

2017-02-15

Who can join

Age: 10 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of stage I, II, or III avascular necrosis (AVN) by MRI or plain film imaging that is related to sickle cell disease
• Clinically moderate to severe pain originating from the hip and/or limitation of movement of the affected hip
• AVN in the contralateral hip allowed, regardless of stage, if the primary hip is eligible If both hips eligible, most symptomatic hip enrolled

You may not qualify if…

• Non-sickle cell arthropathies
• Concurrent chronic steroids
• Chronic transfusion therapy
• Alcoholism

Where it is running

• Children's Hospital of Oakland — Oakland, California, United States
• University of North Carolina School of Medicine — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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