Comparison of Radiation Therapy With or Without Combination Chemotherapy Following Surgery in Treating Patients With Stage I or Stage II Endometrial Cancer

Completed · Phase 3

Conditions studied: Endometrial Cancer

In brief

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor tissue. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if radiation therapy is more effective with or without combination chemotherapy for endometrial cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without combination chemotherapy following surgery in treating patients who have stage I or stage II endometrial cancer.

Key facts

Study ID

NCT00006027

Run by

Radiation Therapy Oncology Group

Starts

2000-08-01

Last updated by the study team

2020-10-22

Who can join

Age: 18 and older, up to 120. Sex: female. Healthy volunteers: not accepted.

Where it is running

• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• Community Hospital of Los Gatos — Los Gatos, California, United States
• Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center — Orange, California, United States
• University of Colorado Cancer Center at University of Colorado Health Sciences Center — Denver, Colorado, United States
• MBCCOP - Hawaii — Honolulu, Hawaii, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
• Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support — Bethesda, Maryland, United States
• Tufts - New England Medical Center — Boston, Massachusetts, United States
• University of Minnesota Cancer Center — Minneapolis, Minnesota, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Ellis Fischel Cancer Center at University of Missouri - Columbia — Columbia, Missouri, United States
• Cooper University Hospital — Camden, New Jersey, United States
• State University of New York Health Science Center at Brooklyn — Brooklyn, New York, United States
• Memorial Sloan-Kettering Cancer Center — New York, New York, United States
• Long Island Cancer Center at Stony Brook University Hospital — Stony Brook, New York, United States
• Lineberger Comprehensive Cancer Center, UNC — Chapel Hill, North Carolina, United States
• Duke Comprehensive Cancer Center — Durham, North Carolina, United States
• Comprehensive Cancer Center at Wake Forest University — Winston-Salem, North Carolina, United States
• University of Oklahoma College of Medicine — Oklahoma City, Oklahoma, United States
• Penn State Cancer Institute at Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
• Kimmel Cancer Center at Thomas Jefferson University - Philadelphia — Philadelphia, Pennsylvania, United States
• Hollings Cancer Center at Medical University of South Carolina — Charleston, South Carolina, United States
• Brookview Research, Inc. — Nashville, Tennessee, United States
• University of Texas Medical Branch — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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