Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma

Completed · Phase 1

Conditions studied: Brain Tumor, Central Nervous System Tumor

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of temozolomide plus lomustine followed by radiation therapy in treating patients who have high-grade malignant glioma.

Key facts

Study ID

NCT00006024

Run by

Children's Oncology Group

People needed

32

Starts

2000-11-01

Expected to finish

2006-09-01

Last updated by the study team

2014-02-13

Who can join

Age: 3 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of South Alabama Medical Center — Mobile, Alabama, United States
• Phoenix Children's Hospital — Phoenix, Arizona, United States
• Arizona Cancer Center — Tucson, Arizona, United States
• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Southern California Permanente Medical Group — Downey, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
• Loma Linda University Medical Center — Loma Linda, California, United States
• Jonathan Jaques Children's Cancer Center — Long Beach, California, United States
• Children's Hospital Los Angeles — Los Angeles, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• Children's Hospital Central California — Madera, California, United States
• Children's Hospital of Oakland — Oakland, California, United States
• Chao Family Comprehensive Cancer Center — Orange, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Lucile Packard Children's Hospital at Stanford — Palo Alto, California, United States
• Sutter Cancer Center — Sacramento, California, United States
• University of California Davis Medical Center — Sacramento, California, United States
• Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego — San Diego, California, United States
• Children's Hospital San Diego — San Diego, California, United States
• Kaiser Permanente Medical Center - San Francisco Geary Campus — San Francisco, California, United States
• UCSF Comprehensive Cancer Center — San Francisco, California, United States
• Santa Barbara Cottage Hospital — Santa Barbara, California, United States
• University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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