SU5416 in Treating Patients With Metastatic Melanoma That Has Been Previously Treated
Stopped early · Phase 2
Conditions studied: Recurrent Melanoma, Stage IV Melanoma
In brief
SU5416 may stop the growth of malignant melanoma by stopping blood flow to the tumor. Phase II trial to study the effectiveness of SU5416 in treating patients who have metastatic melanoma that has been previously treated
Key facts
- Study ID
- NCT00006003
- Run by
- National Cancer Institute (NCI)
- People needed
- 35
- Starts
- 2000-07-01
- Last updated by the study team
- 2013-01-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed melanoma with documented metastatic disease
- In transit metastases allowed
- Lesion accessible for biopsy
- Measurable disease
- Greater than 20 mm by conventional techniques ORgreater than 10 mm by spiral CT
- Documented progressive disease by radiologic study or physical examination
- Known history of CNS metastasis who have had treatment, are neurologicallystable, and do not require intravenous antibiotics or anticonvulsants eligibleprovided oral steroids are not required and brain scan (CT or MRI) showsabsence of active or residual disease
- If neurologic signs or symptoms suggestive of CNS metastasis, negative brain scan required
- Performance status - WHO 0-2
- At least 12 weeks
- WBC at least 3,000/mm\^3
- Platelet count at least 100,000/mm\^3
- Bilirubin no greater than 1.5 mg/dL
- Transaminases no greater than 2.5 times upper limit of normal
- Creatinine no greater than 1.5 mg/dL
- Creatinine clearance at least 60 mL/min
- No uncompensated coronary artery disease
- No history of myocardial infarction or severe/unstable angina within past 6 months
- No severe peripheral vascular disease associated with diabetes mellitus
- No deep venous or arterial thrombosis within past 3 months
- No pulmonary embolism within past 3 months
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No other significant uncontrolled underlying medical or psychiatric illness
Where it is running
- University of Chicago Comprehensive Cancer Center — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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