BMS-214662 in Treating Patients With Solid Tumors
Completed · Phase 1
Conditions studied: Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
In brief
Phase I trial to study the effectiveness of BMS-214662 in treating patients who have solid tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die
Key facts
- Study ID
- NCT00005973
- Run by
- National Cancer Institute (NCI)
- People needed
- 36
- Starts
- 2000-04-01
- Last updated by the study team
- 2013-01-23
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of malignant solid tumor for which a standard curative therapy does not exist
- Performance status - Karnofsky 70-100%
- At least 6 months
- WBC at least 3,000/mm\^3
- Absolute neutrophil count at least 1,500/mm\^3
- Platelet count at least 100,000/mm\^3
- Hemoglobin at least 10.0 g/dL
- Bilirubin no greater than 2.0 mg/dL
- AST no greater than 2 times upper limit of normal
- Albumin at least 3.0 g/dL
- Creatinine no greater than 1.5 mg/dL
- No uncontrolled heart disease
- No history of clinically significant cardiac arrhythmia that could be exacerbated by QT interval prolongation
- Corrected QT interval no greater than 450 milliseconds
- Must not require total parenteral nutrition
- No manifestations of malabsorption syndrome due to prior surgery, gastrointestinal disease, or unknown reasons
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No signs or symptoms of acute infection requiring systemic therapy
- No grade 3 or 4 neurotoxicity from prior anticancer treatment or neuropathy from any cause
- No confusion, disorientation, or psychiatric illness that may preclude study
- No more than 3 prior chemotherapy regimens
- At least 4 weeks since prior chemotherapy (6 weeks since prior nitrosoureas or mitomycin) and recovered
- No other concurrent antineoplastic agents
Where it is running
- M D Anderson Cancer Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
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