Comparison of Three Treatment Regimens in Treating Patients With Relapsed or Refractory Acute Myelogenous Leukemia

Completed · Phase 2

Conditions studied: Leukemia

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as gemtuzumab ozogamicin can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Combining more than one drug or combining monoclonal antibody with chemotherapy may kill more cancer cells. It is not yet known which treatment regimen is more effective for acute myelogenous leukemia. PURPOSE: Randomized phase II trial to compare the effectiveness of three treatment regimens in treating patients who have relapsed or refractory acute myelogenous leukemia.

Key facts

Study ID

NCT00005962

Run by

Eastern Cooperative Oncology Group

Starts

2000-10-04

Expected to finish

2007-06-01

Last updated by the study team

2023-06-22

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Cancer Center and Beckman Research Institute, City of Hope — Duarte, California, United States
• Veterans Affairs Medical Center - Palo Alto — Palo Alto, California, United States
• Stanford University Medical Center — Stanford, California, United States
• CCOP - Colorado Cancer Research Program, Inc. — Denver, Colorado, United States
• CCOP - Christiana Care Health Services — Wilmington, Delaware, United States
• Veterans Affairs Medical Center - Gainsville — Gainesville, Florida, United States
• Veterans Affairs Medical Center - Miami — Miami, Florida, United States
• H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
• Veterans Affairs Medical Center - Tampa (Haley) — Tampa, Florida, United States
• Robert H. Lurie Comprehensive Cancer Center, Northwestern University — Chicago, Illinois, United States
• Veterans Affairs Medical Center - Lakeside Chicago — Chicago, Illinois, United States
• CCOP - Central Illinois — Decatur, Illinois, United States
• CCOP - Evanston — Evanston, Illinois, United States
• CCOP - Illinois Oncology Research Association — Peoria, Illinois, United States
• CCOP - Carle Cancer Center — Urbana, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• Veterans Affairs Medical Center - Indianapolis (Roudebush) — Indianapolis, Indiana, United States
• CCOP - Cedar Rapids Oncology Project — Cedar Rapids, Iowa, United States
• CCOP - Iowa Oncology Research Association — Des Moines, Iowa, United States
• Holden Comprehensive Cancer Center at The University of Iowa — Iowa City, Iowa, United States
• MBCCOP - LSU Health Sciences Center — New Orleans, Louisiana, United States
• CCOP - Ochsner — New Orleans, Louisiana, United States
• Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
• New England Medical Center Hospital — Boston, Massachusetts, United States
• CCOP - Scottsdale Oncology Program — Scottsdale, Arizona, United States

Full record on ClinicalTrials.gov

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