Learning and Behavior Problems in Children With Chronic Granulomatous Disease and Related Disorders

Completed

Conditions studied: Chediak Higashi Syndrome, Chronic Granulomatous Disease, Job's Syndrome, Leukocyte Disorder

In brief

This study will try to determine what causes learning, behavioral and emotional problems in children with chronic granulomatous disease (GCD) and other phagocyte disorders. (Phagocytes are a type of white blood cell.) Children with these disorders have frequent severe infections that require hospitalization, sometimes for long periods of time. Many of them also have problems with school, learning, behavior, anxiety and depression. This study will explore whether these latter problems are a direct result of the illness itself or are a consequence of frequent, long hospitalizations, or are due to other factors. Test findings in these children will be compared with those of children with cystic fibrosis-another disease that causes frequent infections requiring prolonged hospitalization. Patients age 2 or older with GCD or other phagocytic disorders or cystic fibrosis may be eligible for this study. Participants (or a parent or guardian) will complete questionnaires including personal information such as age, gender and marital status, a family medical history, and information on their illness. Patients will be given various psychological and intelligence tests, and they and their parents or guardians will be interviewed by a child psychiatrist. The tests and interviews take a total of about 5 hours and are given in two or three separate sessions. The tests may reveal problems such as learning disorders, attention-deficit hyperactivity disorder, anxiety, or depression. If any of these problems are identified, appropriate referrals will be made for specialized services, such as special school placement, tutoring, or counseling.

Key facts

Study ID

NCT00005933

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

150

Starts

2000-06-01

Expected to finish

2005-07-01

Last updated by the study team

2008-03-04

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Presence of a confirmed diagnosis of CGD or other phagocytic disorder.
• Age 2 or older.
• English spoken in the home.

You may not qualify if…

• Unconfirmed phagocytic disorder.
• Under age 2.
• First language is other than English.

Where it is running

• National Institute of Allergy and Infectious Diseases (NIAID) — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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