Genetics of Recurrent Early-Onset Depression

Completed

Conditions studied: Depression

In brief

This nationwide study will create a DNA collection to permit qualified scientists to search for depression-related genes. More than 750 families with at least two siblings who have experienced major depression are needed for the study. Participants will be interviewed about psychiatric and family history, and will be asked to provide a small blood specimen. The identification of predisposing genes can lead to greater understanding of the brain mechanisms involved in severe depression which can in turn lead to the discovery of new treatments. A Certificate of Confidentiality from the federal government ensures that all information will be strictly confidential. Blood specimens are identified only by code number (not by name). Reimbursement is provided.

Key facts

Study ID

NCT00005914

Run by

Stanford University

People needed

2533

Starts

1999-10-01

Expected to finish

2005-10-01

Last updated by the study team

2019-04-19

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Families that have at least TWO ADULT SIBLINGS (brother/brother; sister/sister; brother/sister) who have experienced major depression.
• Depression must be RECURRENT (more than one episode).
• Depression must have started at age 30 or less in one sibling, and at age 40 or less in the other sibling.

You may not qualify if…

• Participants cannot have Bipolar I (manic-depressive) disorder or schizophrenia.

Where it is running

• Rush Presbyterian - Saint Luke's Med Ctr — Chicago, Illinois, United States
• Univ of Iowa Hosp and Clinic — Iowa City, Iowa, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• New York State Psychiatric Institute / Columbia Univ — New York, New York, United States
• Univ of Pennsylvania — Philadelphia, Pennsylvania, United States
• Univ of Pittsburgh / Western Psychiatric Inst and Clinic — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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