S9920 Busulfan Compared With Cyclophosphamide in Patients Undergoing Total-Body Irradiation Plus Peripheral Stem Cell Transplantation for Advanced Myelodysplastic Syndrome or Related Acute Myeloid Leukemia
Completed · Phase 3
Conditions studied: Leukemia, Myelodysplastic Syndromes
In brief
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells. It is not yet known if total-body irradiation plus peripheral stem cell transplantation is more effective with busulfan or with cyclophosphamide for myelodysplastic syndrome or acute myeloid leukemia. PURPOSE: Randomized phase III trial to compare the effectiveness of busulfan with that of cyclophosphamide in patients undergoing total-body irradiation plus peripheral stem cell transplantation for advanced myelodysplastic syndrome or related acute myeloid leukemia.
Key facts
- Study ID
- NCT00005866
- Run by
- SWOG Cancer Research Network
- People needed
- 240
- Starts
- 2000-02-01
- Expected to finish
- 2006-03-01
- Last updated by the study team
- 2015-03-06
Who can join
Age: 16 and older, up to 55. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Cancer Center — Tucson, Arizona, United States
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Alta Bates Comprehensive Cancer Center — Berkeley, California, United States
- Cancer Center and Beckman Research Institute, City of Hope — Duarte, California, United States
- Scripps Clinic — La Jolla, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
- St. Joseph Hospital - Orange — Orange, California, United States
- Chao Family Comprehensive Cancer Center — Orange, California, United States
- Sutter Cancer Center — Sacramento, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- Stanford University Medical Center — Stanford, California, United States
- Northern California Cancer Specialists Medical Clinic — Walnut Creek, California, United States
- University of Colorado Cancer Center — Denver, Colorado, United States
- Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
- Queen's Medical Center — Honolulu, Hawaii, United States
- St. Francis Medical Center — Honolulu, Hawaii, United States
- Mountain States Tumor Institute — Boise, Idaho, United States
- Loyola University Medical Center — Maywood, Illinois, United States
- University of Kansas Medical Center — Kansas City, Kansas, United States
- CCOP - Wichita — Wichita, Kansas, United States
- Cancer Center of Kansas - Wichita — Wichita, Kansas, United States
- Albert B. Chandler Medical Center, University of Kentucky — Lexington, Kentucky, United States
- Lucille Parker Markey Cancer Center, University of Kentucky — Lexington, Kentucky, United States
- Good Samaritan Medical Center — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.