Chemotherapy With or Without Biological Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

Completed · Phase 2

Conditions studied: Prostate Cancer

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. It is not yet known which treatment regimen is more effective in treating metastatic prostate cancer. PURPOSE: Randomized phase II trial to compare the effectiveness of combination chemotherapy with that of chemotherapy plus biological therapy in treating patients who have progressive or metastatic prostate cancer that has not responded to hormone therapy.

Key facts

Study ID

NCT00005847

Run by

Eastern Cooperative Oncology Group

Starts

2001-04-05

Last updated by the study team

2023-06-22

Who can join

Age: 18 and older, up to 120. Sex: male. Healthy volunteers: not accepted.

Where it is running

• CCOP - Colorado Cancer Research Program, Incorporated — Denver, Colorado, United States
• Emory University Hospital - Atlanta — Atlanta, Georgia, United States
• Veterans Affairs Medical Center - Atlanta (Decatur) — Decatur, Georgia, United States
• CCOP - Carle Cancer Center — Urbana, Illinois, United States
• Tufts - New England Medical Center — Boston, Massachusetts, United States
• CCOP - Kalamazoo — Kalamazoo, Michigan, United States
• Mayo Clinic Cancer Center — Rochester, Minnesota, United States
• CCOP - Metro-Minnesota — Saint Louis Park, Minnesota, United States
• CCOP - Northern New Jersey — Hackensack, New Jersey, United States
• Cancer Institute of New Jersey — New Brunswick, New Jersey, United States
• MBCCOP-Our Lady of Mercy Cancer Center — The Bronx, New York, United States
• CCOP - Merit Care Hospital — Fargo, North Dakota, United States
• Ireland Cancer Center — Cleveland, Ohio, United States
• CCOP - Toledo Community Hospital — Toledo, Ohio, United States
• CCOP - Geisinger Clinic and Medical Center — Danville, Pennsylvania, United States
• Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
• CCOP - Sioux Community Cancer Consortium — Sioux Falls, South Dakota, United States
• CCOP - St. Vincent Hospital Cancer Center, Green Bay — Green Bay, Wisconsin, United States
• Medical College of Wisconsin Cancer Center — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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