Dynamic Aspects of Amino Acid Metabolism

Status unconfirmed

Conditions studied: Kidney Diseases

In brief

This protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of several amino acids. The major hypothesis to be tested is that the splanchic bed (intestine and liver) conserves essential amino acids and metabolites while synthesizing and metabolizing nonessential amino acids. The aims of the study include defining the relative roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine, methionine and other amino acids. Emphasis will also be placed on studies of the transamination of alpha-ketoisocaproic acid (KIC) to leucine since this reaction is of potential importance in the design of nutritional regimens for patients with renal disease.

Key facts

Study ID

NCT00005767

Run by

National Center for Research Resources (NCRR)

Last updated by the study team

2005-06-24

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• normal weight-for-height weight 50-80 kg
• normal physical activity
• no significant medical history
• healthy by medical exam and lab blood testing

You may not qualify if…

• subjects who exercise vigorously
• subjects who smoke

Where it is running

• University of Vermont — Burlington, Vermont, United States (enrolling)

Full record on ClinicalTrials.gov

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