Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Completed · Phase 3

Conditions studied: Leukemia

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which regimen of combination chemotherapy is more effective for childhood acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is comparing different regimens of combination chemotherapy to see how well they work in treating children with acute lymphoblastic leukemia.

Key facts

Study ID

NCT00005585

Run by

Children's Oncology Group

People needed

838

Starts

2000-04-01

Last updated by the study team

2023-04-06

Who can join

Age: 1 and older, up to 9. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of South Alabama Cancer Research Institute — Mobile, Alabama, United States
• Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
• Stanford Cancer Center at Stanford University Medical Center — Palo Alto, California, United States
• Sutter Cancer Center — Sacramento, California, United States
• University of California Davis Cancer Center — Sacramento, California, United States
• Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego — San Diego, California, United States
• Children's Hospital and Health Center - San Diego — San Diego, California, United States
• Kaiser Permanente Medical Center - Santa Clara Kiely Campus — Santa Clara, California, United States
• Yale Comprehensive Cancer Center — New Haven, Connecticut, United States
• Broward General Medical Center — Fort Lauderdale, Florida, United States
• Children's Hospital of Southwest Florida — Fort Myers, Florida, United States
• University of Florida Shands Cancer Center — Gainesville, Florida, United States
• Joe DiMaggio Children's Hospital at Memorial — Hollywood, Florida, United States
• Nemours Children's Clinic — Jacksonville, Florida, United States
• University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States
• Miami Children's Hospital — Miami, Florida, United States
• Baptist-South Miami Regional Cancer Program — Miami, Florida, United States
• Florida Hospital Cancer Institute — Orlando, Florida, United States
• Nemours Children's Clinic-Orlando — Orlando, Florida, United States
• Sacred Heart Children's Hospital — Pensacola, Florida, United States
• All Children's Hospital — St. Petersburg, Florida, United States
• St. Joseph's Children's Hospital of Tampa — Tampa, Florida, United States
• Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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