Measurement of Outcome of Surgical Treatment in Patients With Acromegaly

Status unconfirmed

Conditions studied: Acromegaly

In brief

OBJECTIVES: I. Compare growth hormone (GH) levels at baseline and after glucose suppression measured with both a polyclonal radioimmunoassay and a highly sensitive immunoradiometric assay (IRMA) in patients with acromegaly and normal volunteers. II. Measure the levels of IGF-I and its binding protein, IGFBP-3, in these cohorts. III. Determine any correlation between levels of IGF-I and IGFBP-3 and GH suppressibility as assessed by sensitive IRMA. IV. Determine if patients who demonstrate biochemical features of mild GH excess are at risk for progression to active disease.

Key facts

Study ID

NCT00005100

Run by

National Center for Research Resources (NCRR)

People needed

165

Starts

1999-09-01

Last updated by the study team

2005-06-24

Who can join

Age: 20 and older, up to 75. Sex: any. Healthy volunteers: accepted.

Where it is running

• Columbia University College of Physicians and Surgeons — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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