Combination Treatment Using Capravirine (AG1549), Nelfinavir, and Two Nucleoside Reverse Transcriptase Inhibitors in HIV Patients Who Failed Initial Combination Therapy

Completed · Phase 2

Conditions studied: HIV Infections

In brief

The purpose of this study is to look at the effectiveness of an anti-HIV drug combination that adds capravirine in patients who have failed their first drug combination treatment.

Key facts

Study ID

NCT00004985

Run by

Agouron Pharmaceuticals

People needed

75

Starts

2000-01-01

Last updated by the study team

2005-06-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients may be eligible for this trial if they:
• Are HIV-positive.
• Have a CD4 cell count more than 50/mm3.
• Are at least 18 years old.
• Have adequate blood, kidney, and liver functions.
• Are currently taking an anti-HIV drug combination of an NNRTI plus 1 or more NRTIs for more than 28 days and are failing that combination.

You may not qualify if…

• Patients will not be eligible for this trial if they:
• Have had any protease inhibitor or capravirine treatment.
• Have been given any drug that interferes with their immune system or with the study drugs within 28 days of study entry.
• Have had radiation therapy within 28 days of study entry.

Where it is running

• Phoenix Body Positive — Phoenix, Arizona, United States
• Pacific Oaks Med Group — Beverly Hills, California, United States
• First Choice Medical — Palm Springs, California, United States
• Apogee Med Group — San Diego, California, United States
• Saint Francis Mem Hosp / HIV Care Unit — San Francisco, California, United States
• Kaiser Foundation Hospital — San Francisco, California, United States
• Harbor - UCLA Med Ctr — Torrance, California, United States
• Univ of Colorado Health Sciences Ctr — Denver, Colorado, United States
• Bach and Godofsky — Bradenton, Florida, United States
• Clin Research of West Florida — Clearwater, Florida, United States
• Community Health Care — Fort Lauderdale, Florida, United States
• Therafirst Med Ctr — Fort Lauderdale, Florida, United States
• South Shore Hosp — Miami, Florida, United States
• Immunity Care and Research Inc — Miami Beach, Florida, United States
• Orange County Health Dept — Orlando, Florida, United States
• Infectious Diseases Associates — Sarasota, Florida, United States
• Hillsborough County Health Dept — Tampa, Florida, United States
• Treasure Coast Infectious Disease Consultants — Vero Beach, Florida, United States
• Polk County Health Dept — Winter Haven, Florida, United States
• AIDS Research Consortium of Atlanta — Atlanta, Georgia, United States
• Braude Mermin Spivey MD PC — Atlanta, Georgia, United States
• Massachusetts Gen Hosp — Boston, Massachusetts, United States
• Fenway Community Health Ctr — Boston, Massachusetts, United States
• VAMC New Jersey Healthcare System — East Orange, New Jersey, United States
• Jersey Shore Med Ctr — Neptune City, New Jersey, United States

Full record on ClinicalTrials.gov

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