Homoharringtonine Compared With Hydroxyurea for Chronic Myelogenous Leukemia That Has Not Responded to Interferon Alfa

Stopped early · Phase 3

Conditions studied: Leukemia

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known if homoharringtonine is more effective than hydroxyurea for chronic myelogenous leukemia that has not responded to interferon alfa. PURPOSE: Randomized phase III trial to compare the effectiveness of homoharringtonine with that of hydroxyurea in treating patients who have chronic myelogenous leukemia that has not responded to interferon alfa.

Key facts

Study ID

NCT00004933

Run by

Alliance for Clinical Trials in Oncology

People needed

5

Starts

2000-01-01

Expected to finish

2001-05-01

Last updated by the study team

2016-07-04

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• MBCCOP - University of South Alabama — Mobile, Alabama, United States
• CCOP - Greater Phoenix — Phoenix, Arizona, United States
• Veterans Affairs Medical Center - Phoenix (Hayden) — Phoenix, Arizona, United States
• Veterans Affairs Medical Center - Tucson — Tucson, Arizona, United States
• Arizona Cancer Center — Tucson, Arizona, United States
• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Veterans Affairs Medical Center - Little Rock (McClellan) — Little Rock, Arkansas, United States
• University of California San Diego Cancer Center — La Jolla, California, United States
• Veterans Affairs Medical Center - Long Beach — Long Beach, California, United States
• USC/Norris Comprehensive Cancer Center — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• Beckman Research Institute, City of Hope — Los Angeles, California, United States
• Veterans Affairs Outpatient Clinic - Martinez — Martinez, California, United States
• CCOP - Bay Area Tumor Institute — Oakland, California, United States
• Chao Family Comprehensive Cancer Center — Orange, California, United States
• University of California Davis Medical Center — Sacramento, California, United States
• UCSF Cancer Center and Cancer Research Institute — San Francisco, California, United States
• Veterans Affairs Medical Center - San Francisco — San Francisco, California, United States
• CCOP - Santa Rosa Memorial Hospital — Santa Rosa, California, United States
• David Grant Medical Center — Travis Air Force Base, California, United States
• Veterans Affairs Medical Center - Denver — Denver, Colorado, United States
• University of Colorado Cancer Center — Denver, Colorado, United States
• CCOP - Christiana Care Health Services — Wilmington, Delaware, United States
• Lombardi Cancer Center, Georgetown University — Washington D.C., District of Columbia, United States
• Veterans Affairs Medical Center - Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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