Carotid Revascularization Endarterectomy Versus Stenting Trial

Completed · Not applicable

Conditions studied: Atherosclerosis, Stroke, Carotid Stenosis, Cerebral Infarction, Myocardial Infarction

In brief

The purpose of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is to compare the relatively new procedure of stent-assisted carotid angioplasty (CAS) to the traditional and accepted surgical approach of carotid endarterectomy (CEA) for the treatment of carotid artery stenosis to prevent recurrent strokes in those patients who have had a TIA (transient ischemic attack) or a mild stroke within the past 6 months (symptomatic) and in those patients who have not had any symptoms within the past 6 months (asymptomatic).

Key facts

Study ID

NCT00004732

Run by

Rutgers, The State University of New Jersey

People needed

2502

Starts

2000-12-01

Expected to finish

2016-12-01

Last updated by the study team

2017-05-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Symptomatic patients with recent neurological events (TIA or non-disabling stroke) with an associated carotid stenosis greater than or equal to 50% by angiography or greater than or equal to 70% by ultrasound or greater than or equal to 70% by Computed Tomography Angiography (CTA) or Magnetic Resonance Angiography (MRA) are eligible for randomization.
• Asymptomatic patients with no recent (in the last 6 months) neurological events referable to the study with artery and carotid stenosis (patients with symptoms beyond 180 days are considered asymptomatic) greater than or equal to 60% by angiography or greater than or equal to 70% by ultrasound or greater than or equal to 80% by CTA or MRA are eligible for randomization.

You may not qualify if…

• Conditions that: (1) interfere with the evaluation of endpoints, (2) are known to interfere with the completion of CEA or CAS, or (3) affect the likelihood of survival for the study period (4 years). Chronic atrial fibrillation and/or anti-coagulation or episodic atrial fibrillation within the last 6 months.

Where it is running

• Dignity Health dba St. Joseph's Hospital & Medical Center — Phoenix, Arizona, United States
• Mayo Clinic Arizona — Scottsdale, Arizona, United States
• The Arizona Board of Regents for the University of Arizona — Tucson, Arizona, United States
• Board of Trustees of the University of Arkansas — Little Rock, Arkansas, United States
• USC University Hospital & LA County Hospital — Los Angeles, California, United States
• The Regents of the University of California — Los Angeles, California, United States
• Kaiser Permanente Medical Center — San Diego, California, United States
• Northern California Institute for Research and Education — San Francisco, California, United States
• Catholic Healthcare West — Stockton, California, United States
• Christiana Care Health Services, Inc. — Newark, Delaware, United States
• Morton Plant Hospital — Clearwater, Florida, United States
• Mayo Clinic — Jacksonville, Florida, United States
• Leesburg Medical Center — Leesburg, Florida, United States
• Miami Cardiac & Vascular Institute of Baptist Hospital of Miami, Inc. — Miami, Florida, United States
• Florida Hospital Neuroscience Institute, a division of Adventist Health System/Sunbelt, Inc. — Orlando, Florida, United States
• Orlando Regional Medical Center — Orlando, Florida, United States
• University of South Florida Board of Trustees — Tampa, Florida, United States
• Piedmont Hospital/Fuqua Heart Center — Atlanta, Georgia, United States
• Emory University — Atlanta, Georgia, United States
• St. Joseph's of Atlanta — Atlanta, Georgia, United States
• St. Joseph's Candler Health System — Savannah, Georgia, United States
• Norwestern Memorial Hospital — Chicago, Illinois, United States
• Alexian Brothers Specialty Group — Elk Grove Village, Illinois, United States
• Loyola University of Chicago — Maywood, Illinois, United States
• The Board of Trustees of the University of Alabama for the University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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