Hereditary Deficits in Auditory Processing Leading to Language Impairment
Stopped early
Conditions studied: Auditory Perceptual Disorder, Language Delay, Language Disorder
In brief
Some children with certain language disorders may not properly process the sounds they hear, resulting in language impairments. The purpose of this study is to determine if deficits in auditory temporal processing the way the brain analyzes the timing and patterns of sounds are an inherited trait. Families with auditory temporal processing deficits are sought in order to identify the genes responsible for auditory temporal processing deficits. Children and adults with a diagnosis or history of language impairment in the family and their family members both affected and non-affected are eligible for this two-part study. In Part 1, participants undergo a series of language tests and listening tests to measure various characteristics of how they perceive sound. In Part 2, they are interviewed about language disorders, learning disabilities, and other medical problems of family members. This information is used to construct a pedigree (family tree diagram) showing the pattern of inheritance of family traits. Study subjects whose pedigree indicates that language disorders may be hereditary in their family will provide either a small blood sample (1 to 2 tablespoons) or a tissue specimen obtained from a cheek swab (rubbing the inside of the cheek with a small brush or cotton swabs). The sample will be used to isolate DNA for genetic analysis.
Key facts
- Study ID
- NCT00004570
- Run by
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- People needed
- 875
- Starts
- 1999-01-31
- Expected to finish
- 2018-09-18
- Last updated by the study team
- 2018-09-20
Who can join
Age: 6 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Hearing loss, defined as air conduction pure tone thresholds (250-8000 Hz) exceeding 20 dBHL; air-bone gaps, even in the presence of normal hearing sensitivity, exceeding 10 dBHL; and/or abnormal tympanometry.
- History of chronic (fluid in middle ear for more than 4 months) or recurrent otitis media (more than 4 episodes of acute otitis media in one year)
- History of ear surgery.
- History or diagnosis of a central nervous system disorder, including but not limited to:
- Intracranial tumors
- Cerebrovascular disease
- Degenerative CNS disorder
- CNS trauma
- Encephalitis
- Meningitis
- Auditory neuropathy
- Attention deficit hyperactivity disorder (ADHD)
- Attention deficit disorder (ADD)
- Currently taking medications capable of altering CNS function (e.g. antidepressants, anxiolytics, or a psychostimulant drugs such as ritalin).
- History of treatment with ototoxic medications that may affect ultrahigh frequency hearing (e.g. cisplatin, aminoglycoside antibiotics).
- Unable to provide consent or assent
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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