Pilot Study of Atorvastatin in Children With Chronic Hyperlipidemia Secondary to Nephrotic Syndrome

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Nephrotic Syndrome, Hyperlipidemia

In brief

OBJECTIVES: I. Determine the effect of atorvastatin on the plasma levels of lipids, Lp(a), and apoproteins for treating hyperlipidemia in children with nephrotic syndrome in whom proteinuria and hyperlipidemia persist after other appropriate measures to treat their primary disease have been exhausted. II. Determine the safety and tolerability of atorvastatin in these patients. III. Provide preliminary data for a future investigation into the potential effect that lowering cholesterol levels may have on the rate of progression of renal insufficiency in such patients.

Key facts

Study ID
NCT00004466
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
People needed
5
Starts
1998-10-01
Expected to finish
1999-12-01
Last updated by the study team
2017-09-15

Who can join

Age: 6 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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