Phase III Randomized Study of SYNSORB Pk in Children With E. Coli-Associated Hemolytic Uremic Syndrome
Stopped early · Phase 3 · Has a placebo group
Conditions studied: Hemolytic Uremic Syndrome
In brief
OBJECTIVES: I. Determine the effect of SYNSORB Pk therapy on mortality and frequency of severe extrarenal complications observed in children with acute stage E. coli-associated hemolytic uremic syndrome. II. Determine the effect of SYNSORB Pk therapy on the need for the duration of dialysis in these patients. III. Determine the effect of SYNSORB Pk therapy on the recovery of renal function and resolution of urinary abnormalities in these patients.
Key facts
- Study ID
- NCT00004465
- Run by
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- People needed
- 145
- Starts
- 1997-07-27
- Expected to finish
- 2001-04-14
- Last updated by the study team
- 2017-06-01
Who can join
Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Children's Hospital of Denver — Denver, Colorado, United States
- Alfred I. Dupont Institute — Wilmington, Delaware, United States
- Emory University School of Medicine — Atlanta, Georgia, United States
- Medical College of Georgia Hospital and Clinics — Augusta, Georgia, United States
- Indiana University Cancer Center — Indianapolis, Indiana, United States
- Boston Floating Hospital Infants and Children — Boston, Massachusetts, United States
- St. Barnabas Medical Center — Livingston, New Jersey, United States
- Robert Wood Johnson Medical School — New Brunswick, New Jersey, United States
- Children's Hospital at St. Joseph's — Paterson, New Jersey, United States
- Maimonides Medical Center — Brooklyn, New York, United States
- Children's Hospital of Buffalo — Buffalo, New York, United States
- North Shore University Hospital — Manhasset, New York, United States
- Long Island Jewish Medical Center — New Hyde Park, New York, United States
- Weill Medical College of Cornell University — New York, New York, United States
- University of Rochester Medical Center — Rochester, New York, United States
- State University of New York Health Sciences Center - Stony Brook — Stony Brook, New York, United States
- Jack D. Weiler Hospital of the Albert Einstein College of Medicine — The Bronx, New York, United States
- New York Medical College — Valhalla, New York, United States
- Bowman Gray School of Medicine — Winston-Salem, North Carolina, United States
- Ohio State University Children's Hospital — Columbus, Ohio, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
- University of Virginia — Charlottesville, Virginia, United States
- Children's Hospital of the King's Daughters — Norfolk, Virginia, United States
- West Virginia University Hospitals — Morgantown, West Virginia, United States
Full record on ClinicalTrials.gov
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