Study of High Dose Cyclophosphamide in Patients With Severe Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Completed · Phase 2

Conditions studied: Aplastic Anemia, Paroxysmal Hemoglobinuria, Nocturnal

In brief

OBJECTIVES: I. Confirm the efficacy demonstrated in a pilot study using high dose cyclophosphamide in patients with severe aplastic anemia. II. Determine whether the addition of filgrastim (G-CSF) to high dose cyclophosphamide shortens the time to recovery in these patients. III. Determine whether this regimen is efficacious in treating paroxysmal nocturnal hemoglobinuria.

Key facts

Study ID

NCT00004464

Run by

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

People needed

69

Starts

1996-02-01

Expected to finish

2008-11-11

Last updated by the study team

2019-01-18

Who can join

Age: any, up to 70. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Johns Hopkins Oncology Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.