Randomized Study of Tauroursodeoxycholic Acid in Prophylactic Therapy of Total Parenteral Nutrition Associated Cholestasis in Infants
Completed · Not applicable
Conditions studied: Cholestasis
In brief
OBJECTIVES: I. Determine whether infants treated with tauroursodeoxycholic acid (TUDCA) have a lower peak direct bilirubin, ALT, AST, glutamyltranspeptidase levels and a reduced duration of cholestasis compared to the nontreatment arm. II. Determine the significance of lower birth weight and longer duration of total parenteral nutrition (TPN) on increasing risk of TPN associated cholestasis and increasing benefit from TUDCA therapy. III. Determine whether TUDCA therapy leads to significant reduction in the appearance of biliary tract sludge and/or stone formation in these infants. IV. Determine whether TUDCA therapy leads to reduced urinary excretion of potentially hepatotoxic bile acids as compared to the untreated arm matched for birth weight and duration of TPN.
Key facts
- Study ID
- NCT00004410
- Run by
- Children's Hospital Medical Center, Cincinnati
- People needed
- 50
- Starts
- 1998-06-01
- Expected to finish
- 2002-03-01
- Last updated by the study team
- 2015-03-25
Who can join
Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Children's Hospitals and Clinics - Minneapolis — Minneapolis, Minnesota, United States
- University of Mississippi Medical Center — Jackson, Mississippi, United States
- Children's Hospital Medical Center - Cincinnati — Cincinnati, Ohio, United States
Full record on ClinicalTrials.gov
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