Study of the Pathogenesis and Pathophysiology of Familial Neurohypophyseal Diabetes Insipidus

Completed

Conditions studied: Diabetes Insipidus, Diabetes Insipidus, Neurohypophyseal

In brief

OBJECTIVES: I. Determine whether diverse mutations of the vasopressin-neurophysin II (AVP-NPII) gene cause autosomal dominant familial neurohypophyseal diabetes insipidus by directing the production of an abnormal preprohormone. II. Determine whether the AVP-NPII gene-directed preprohormone accumulates and destroys magnocellular neurons because it cannot be folded and processed efficiently.

Key facts

Study ID

NCT00004363

Run by

National Center for Research Resources (NCRR)

Starts

1995-12-01

Last updated by the study team

2005-06-24

Who can join

Age: 1 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Northwestern University Medical School — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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