Absorption of Corticosteroids in Children With Juvenile Dermatomyositis

Completed · Phase 2

Conditions studied: Vasculitis, Hypersensitivity, Connective Tissue Diseases, Dermatomyositis, Vasculitis

In brief

Juvenile dermatomyositis (JDM) is a connective tissue disease that causes skin rash and weak muscles in children. The purpose of this study is to measure the absorption of oral prednisolone and intravenous (IV) methylprednisolone and to determine levels of disease activity indicators in the blood. These levels will be compared to see if there are patterns specific to active and less active JDM.

Key facts

Study ID

NCT00004357

Run by

Northwestern University

People needed

6

Starts

1997-09-01

Expected to finish

2008-02-01

Last updated by the study team

2011-07-22

Who can join

Age: 4 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Juvenile dermatomyositis with evidence of active vasculitis
• Elevated von Willebrand factor antigen prior to study entry
• Elevated neopterin level prior to study entry

You may not qualify if…

• Severe renal involvement
• Critically ill or clinically unstable
• Diseases other than dermatomyositis with vasculitis

Where it is running

• Children's Memorial Hospital, Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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