Phase II Study of Dietary Cholesterol for Smith-Lemli-Opitz Syndrome

Status unconfirmed · Phase 2

Conditions studied: Smith-Lemli-Opitz Syndrome

In brief

OBJECTIVES: I. Examine the intestinal absorption of dietary cholesterol in patients with Smith-Lemli-Opitz syndrome. II. Measure the effect of dietary cholesterol on plasma sterol composition. III. Quantify basal cholesterol synthesis, turnover of cholesterol and 7-dehydrocholesterol, and the effects of dietary cholesterol on these parameters. IV. Identify fecal bile acid excretion quantitatively and qualitatively in these patients. V. Compare the incorporation of deuterated water into plasma cholesterol, 7-dehydrocholesterol, and other intermediates, and assess the effect of dietary cholesterol on this incorporation.

Key facts

Study ID

NCT00004347

Run by

National Center for Research Resources (NCRR)

People needed

5

Starts

1995-11-01

Last updated by the study team

2005-06-24

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Oregon Health and Science University — Portland, Oregon, United States (enrolling)

Full record on ClinicalTrials.gov

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