Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle

Completed

Conditions studied: Hypogonadism, Precocious Puberty

In brief

OBJECTIVES: I. Evaluate the sleep-entrained patterns of gonadotropin-releasing hormone (GnRH) and sex steroid secretion in normal and hypogonadal children. II. Examine the acute effects of sex steroids on the sleep-entrained patterns of GnRH secretion in pubertal children and normal adults, either by stimulation of endogenous production with pulsatile injection or by intravenous infusion of GnRH. III. Examine the role of endogenous opioids by means of opioid receptor blockade in the sex steroid regulation of GnRH secretion in pubertal children and normal adults.

Key facts

Study ID

NCT00004335

Run by

National Center for Research Resources (NCRR)

Starts

1993-04-01

Last updated by the study team

2005-06-24

Who can join

Age: 7 and older, up to 35. Sex: any. Healthy volunteers: accepted.

Where it is running

• University of Michigan Health Systems — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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