Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome

Completed

Conditions studied: Cushing's Syndrome

In brief

OBJECTIVES: I. Evaluate whether chronic hypercortisolemia is specifically toxic to hippocampal cells and causes structural reduction of hippocampal volume in patients with Cushing's syndrome. II. Determine whether reduced hippocampal volume is associated with specific memory dysfunction. III. Examine the relationships of adrenal androgen to hippocampal volume and memory dysfunction. IV. Examine the reversibility of hippocampal structural changes and cognitive dysfunction after cortisol levels are normalized.

Key facts

Study ID

NCT00004326

Run by

National Center for Research Resources (NCRR)

People needed

12

Starts

1994-08-01

Last updated by the study team

2005-06-24

Who can join

Age: 15 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of Michigan Health Systems — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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