Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas
Completed · Phase 3
Conditions studied: Brain and Central Nervous System Tumors
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy, such as temozolomide, carmustine, and lomustine, use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells. PURPOSE: This randomized phase III trial is studying radiation therapy and temozolomide to see how well they work compared to radiation therapy and carmustine or lomustine in treating patients with anaplastic astrocytoma or mixed gliomas.
Key facts
- Study ID
- NCT00004259
- Run by
- Radiation Therapy Oncology Group
- People needed
- 230
- Starts
- 2000-06-01
- Expected to finish
- 2018-05-14
- Last updated by the study team
- 2019-09-12
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Oncology Services Foundation — Phoenix, Arizona, United States
- Enloe Cancer Center at Enloe Medical Center — Chico, California, United States
- North Bay Cancer Center — Fairfield, California, United States
- Solano Radiation Oncology Center — Vacaville, California, United States
- Lynn Regional Cancer Center at Boca Raton Community Hospital - Main Center — Boca Raton, Florida, United States
- University of Florida Shands Cancer Center — Gainesville, Florida, United States
- Baptist Cancer Institute - Jacksonville — Jacksonville, Florida, United States
- Florida Oncology Associates at Southside Cancer Center — Jacksonville, Florida, United States
- Baptist Medical Center South — Jacksonville, Florida, United States
- Integrated Community Oncology Network — Jacksonville Beach, Florida, United States
- Florida Oncology Associates — Orange Park, Florida, United States
- Florida Cancer Center - Palatka — Palatka, Florida, United States
- Flagler Cancer Center — Saint Augustine, Florida, United States
- H. Lee Moffitt Cancer Center and Research Institute at University of South Florida — Tampa, Florida, United States
- John B. Amos Cancer Center — Columbus, Georgia, United States
- St. Joseph Medical Center — Bloomington, Illinois, United States
- Graham Hospital — Canton, Illinois, United States
- Memorial Hospital — Carthage, Illinois, United States
- Eureka Community Hospital — Eureka, Illinois, United States
- Galesburg Clinic — Galesburg, Illinois, United States
- Galesburg Cottage Hospital — Galesburg, Illinois, United States
- InterCommunity Cancer Center of Western Illinois — Galesburg, Illinois, United States
- Mason District Hospital — Havana, Illinois, United States
- Hopedale Medical Complex — Hopedale, Illinois, United States
- Mobile Infirmary Medical Center — Mobile, Alabama, United States
Full record on ClinicalTrials.gov
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