Mitoxantrone and Prednisone With or Without Leflunomide in Treating Patients With Stage IV Prostate Cancer

Completed · Phase 2/Phase 3

Conditions studied: Prostate Cancer

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known if mitoxantrone and prednisone are more effective with or without leflunomide for treating prostate cancer. PURPOSE: Randomized phase II/III trial to compare the effectiveness of mitoxantrone and prednisone with or without leflunomide in treating patients who have stage IV prostate cancer that has not responded to hormone therapy.

Key facts

Study ID

NCT00004071

Run by

Pfizer

Starts

1999-08-01

Expected to finish

2007-09-01

Last updated by the study team

2012-09-11

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

Where it is running

• Comprehensive Cancer Care Specialists of Boca Raton — Boca Raton, Florida, United States
• Florida Cancer Specialists — Fort Myers, Florida, United States
• St. Vincents Comprehensive Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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