Chemotherapy Plus Monoclonal Antibody Therapy in Treating Women With Stage II or Stage IIIA Breast Cancer That Overexpresses HER2
Completed · Phase 2
Conditions studied: Breast Cancer
In brief
Randomized phase II trial to study the effectiveness of chemotherapy with paclitaxel and the monoclonal antibody trastuzumab followed by chemotherapy in treating women who have stage II or stage IIIA breast cancer that overexpresses HER2. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies can locate tumor cells and deliver tumor-killing substances to them without harming normal cells. Combining monoclonal antibody therapy with chemotherapy may kill more tumor cells.
Key facts
- Study ID
- NCT00003992
- Run by
- National Cancer Institute (NCI)
- People needed
- 200
- Starts
- 1999-08-01
- Expected to finish
- 2009-03-01
- Last updated by the study team
- 2013-06-03
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Veterans Affairs Medical Center - Palo Alto — Palo Alto, California, United States
- Stanford University Medical Center — Stanford, California, United States
- CCOP - Colorado Cancer Research Program, Inc. — Denver, Colorado, United States
- H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
- Emory University Hospital - Atlanta — Atlanta, Georgia, United States
- Veterans Affairs Medical Center - Atlanta (Decatur) — Decatur, Georgia, United States
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University — Chicago, Illinois, United States
- Veterans Affairs Medical Center - Chicago (Lakeside) — Chicago, Illinois, United States
- CCOP - Central Illinois — Decatur, Illinois, United States
- CCOP - Evanston — Evanston, Illinois, United States
- CCOP - Illinois Oncology Research Association — Peoria, Illinois, United States
- CCOP - Carle Cancer Center — Urbana, Illinois, United States
- Veterans Affairs Medical Center - Indianapolis (Roudebush) — Indianapolis, Indiana, United States
- CCOP - Cedar Rapids Oncology Project — Cedar Rapids, Iowa, United States
- CCOP - Wichita — Wichita, Kansas, United States
- CCOP - Ochsner — New Orleans, Louisiana, United States
- Johns Hopkins Oncology Center — Baltimore, Maryland, United States
- New England Medical Center Hospital — Boston, Massachusetts, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- CCOP - Ann Arbor Regional — Ann Arbor, Michigan, United States
- CCOP - Kalamazoo — Kalamazoo, Michigan, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- CCOP - Metro-Minnesota — Saint Louis Park, Minnesota, United States
- CCOP - Missouri Valley Cancer Consortium — Omaha, Nebraska, United States
- Trinitas Hospital - Jersey Street Campus — Elizabeth, New Jersey, United States
Full record on ClinicalTrials.gov
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