Chemoembolization in Treating Patients With Primary Liver Cancer or Metastases to the Liver

Completed · Phase 2

Conditions studied: Liver Cancer, Metastatic Cancer

In brief

RATIONALE: Chemoembolization kills tumor cells by blocking the blood flow to the tumor and keeping chemotherapy drugs near the tumor. PURPOSE: Phase II trial to study the effectiveness of chemoembolization in treating patients who have primary liver cancer or metastases to the liver that cannot be surgically removed.

Key facts

Study ID

NCT00003907

Run by

Eastern Cooperative Oncology Group

People needed

50

Starts

1999-12-15

Expected to finish

2012-08-01

Last updated by the study team

2023-07-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Biopsy-proven intrahepatic hepatocellular carcinoma or neuroendocrine tumor.
• Unresectable.
• Bidimensionally measurable disease by Computed Tomography (CT), Magnetic resonance imaging (MRI), or UltraSound Scanning (US) within 6 weeks of registration.
• Evidence of patent portal vasculature by Doppler US, MRI, or angiography.
• Serum total bilirubin < 2.0 mg/dl and serum creatinine < 2.0 mg/dl within 4 weeks of registration.
• Absolute neutrophil count (ANC) > 2000/µl and platelets > 50,000/µl within 4 weeks of registration.
• Expected survival of at least 3 months.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• Age >= 18 years.

You may not qualify if…

• Evidence of extrahepatic disease that is likely to be life-threatening within 3 months, such as brain or symptomatic lung metastases.
• Previous intra-arterial or intra-hepatic chemotherapy or prior systemic chemotherapy within 4 weeks.
• Concurrent malignancy.
• Pregnant or breast-feeding women.
• History of life-threatening contrast allergy.

Where it is running

• Front Range Cancer Specialists — Fort Collins, Colorado, United States
• Baptist Cancer Institute - Jacksonville — Jacksonville, Florida, United States
• Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
• Veterans Affairs Medical Center - Atlanta (Decatur) — Decatur, Georgia, United States
• Rush-Copley Cancer Care Center — Aurora, Illinois, United States
• Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States
• Hematology and Oncology Associates — Chicago, Illinois, United States
• Veterans Affairs Medical Center - Lakeside Chicago — Chicago, Illinois, United States
• Mercy Hospital and Medical Center — Chicago, Illinois, United States
• Swedish Covenant Hospital — Chicago, Illinois, United States
• Hinsdale Hematology Oncology Associates — Hinsdale, Illinois, United States
• Midwest Center for Hematology/Oncology — Joliet, Illinois, United States
• Joliet Oncology-Hematology Associates, Limited - West — Joliet, Illinois, United States
• North Shore Oncology and Hematology Associates, Limited - Libertyville — Libertyville, Illinois, United States
• Hematology Oncology Associates - Skokie — Skokie, Illinois, United States
• Hematology/Oncology of the North Shore at Gross Point Medical Center — Skokie, Illinois, United States
• Carle Cancer Center at Carle Foundation Hospital — Urbana, Illinois, United States
• CCOP - Carle Cancer Center — Urbana, Illinois, United States
• Saint Anthony Memorial Health Centers — Michigan City, Indiana, United States
• Mercy Capitol Hospital — Des Moines, Iowa, United States
• CCOP - Iowa Oncology Research Association — Des Moines, Iowa, United States
• John Stoddard Cancer Center at Iowa Methodist Medical Center — Des Moines, Iowa, United States
• Medical Oncology and Hematology Associates at John Stoddard Cancer Center — Des Moines, Iowa, United States
• Medical Oncology and Hematology Associates at Mercy Cancer Center — Des Moines, Iowa, United States
• Mercy Cancer Center at Mercy Medical Center - Des Moines — Des Moines, Iowa, United States

Full record on ClinicalTrials.gov

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