Radiation Therapy With or Without Optional Tamoxifen in Treating Women With Ductal Carcinoma in Situ
Completed · Phase 3
Conditions studied: Breast Cancer
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen by the tumor cells. It is not yet known if radiation therapy is more effective than observation, with or without tamoxifen, in treating ductal carcinoma in situ. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with that of observation, with or without tamoxifen, in treating women who have ductal carcinoma in situ.
Key facts
- Study ID
- NCT00003857
- Run by
- Radiation Therapy Oncology Group
- People needed
- 636
- Starts
- 1999-12-01
- Expected to finish
- 2022-05-20
- Last updated by the study team
- 2022-05-25
Who can join
Age: 26 and older, up to 120. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
- Arizona Oncology Services Foundation — Phoenix, Arizona, United States
- Saint Joseph's Mercy Cancer Center — Hot Springs, Arkansas, United States
- Providence Saint Joseph Medical Center - Burbank — Burbank, California, United States
- Enloe Cancer Center at Enloe Medical Center — Chico, California, United States
- Mount Diablo Regional Cancer Center — Concord, California, United States
- North Bay Cancer Center — Fairfield, California, United States
- Washington Township Hospital — Fremont, California, United States
- Saint Agnes Medical Center — Fresno, California, United States
- Cancer Care Consultants Medical Associates at Daniel Freeman Memorial Hospital — Inglewood, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Providence Holy Cross Cancer Center — Mission Hills, California, United States
- Memorial Medical Center Cancer Services — Modesto, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center — Pomona, California, United States
- Radiological Associates of Sacramento Medical Group, Incorporated — Sacramento, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- CCOP - Santa Rosa Memorial Hospital — Santa Rosa, California, United States
- Torrance Memorial Medical Center — Torrance, California, United States
- John Muir/Mt. Diablo Comprehensive Cancer Center — Walnut Creek, California, United States
- Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital — Whittier, California, United States
- St. Vincent's Medical Center — Bridgeport, Connecticut, United States
- Hospital of Saint Raphael — New Haven, Connecticut, United States
- Eastern Connecticut Hematology and Oncology Associates — Norwich, Connecticut, United States
- Mobile Infirmary Medical Center — Mobile, Alabama, United States
Full record on ClinicalTrials.gov
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