Pentosan Polysulfate in Treating Patients With Gastrointestinal Disturbance Caused by Radiation Therapy

Completed · Phase 3

Conditions studied: Diarrhea, Radiation Enteritis

In brief

RATIONALE: Pentosan polysulfate may be effective in treating side effects of radiation therapy to the abdomen or pelvis. It is not yet known whether pentosan polysulfate is more effective than no further therapy for treating gastrointestinal disturbance caused by previous radiation therapy. PURPOSE: Randomized phase III trial to determine the effectiveness of pentosan polysulfate in treating patients who have inflammation of the rectum, diarrhea, or blood in stools caused by previous radiation therapy to the abdomen and pelvis.

Key facts

Study ID

NCT00003825

Run by

Radiation Therapy Oncology Group

People needed

174

Starts

1999-06-01

Last updated by the study team

2020-10-19

Who can join

Age: any, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Comprehensive Cancer Institute of Huntsville — Huntsville, Alabama, United States
• Huntsville Hospital System — Huntsville, Alabama, United States
• Mobile Infirmary Medical Center — Mobile, Alabama, United States
• Urology Associates - Mobile AL — Mobile, Alabama, United States
• MBCCOP - University of South Alabama — Mobile, Alabama, United States
• Alabama Oncology, LLC — Montgomery, Alabama, United States
• Radiation Oncology Associates of West Alabama — Tuscaloosa, Alabama, United States
• Providence Cancer Therapy Center — Anchorage, Alaska, United States
• Arizona Cancer Center — Tucson, Arizona, United States
• Mount Diablo Medical Center — Concord, California, United States
• California Cancer Center — Fresno, California, United States
• Saint Agnes Cancer Center — Fresno, California, United States
• Glendale Memorial Hospital and Health Center — Glendale, California, United States
• Sutter Health Western Division Cancer Research Group — Greenbrae, California, United States
• University of California San Diego Cancer Center — La Jolla, California, United States
• Loma Linda University Medical Center — Loma Linda, California, United States
• Veterans Affairs Medical Center - Long Beach — Long Beach, California, United States
• Kaiser Permanente Medical Center - Los Angeles — Los Angeles, California, United States
• USC/Norris Comprehensive Cancer Center — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• Beckman Research Institute, City of Hope — Los Angeles, California, United States
• CCOP - Bay Area Tumor Institute — Oakland, California, United States
• Cancer Care Center — Pomona, California, United States
• Radiation Oncology Center - Sacramento — Sacramento, California, United States
• University of Alabama Comprehensive Cancer Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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