Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count

Completed · Phase 3

Conditions studied: Bone Marrow Suppression, Fever, Sweats, and Hot Flashes, Infection, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific

In brief

RATIONALE: Antibiotic therapy may prevent the development of infection in patients with hematologic cancer and the persistent fever caused by a low white blood cell count. It is not yet known which regimen of antibiotics is most effective in preventing infection in these patients. PURPOSE: Randomized phase III trial to study the effectiveness of piperacillin-tazobactam with or without vancomycin in reducing fever in patients who have leukemia, lymphoma, or Hodgkin's disease.

Key facts

Study ID

NCT00003805

Run by

European Organisation for Research and Treatment of Cancer - EORTC

People needed

859

Starts

1997-11-01

Last updated by the study team

2012-09-24

Who can join

Age: 2 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Marlene & Stewart Greenebaum Cancer Center, University of Maryland — Baltimore, Maryland, United States
• Boston Medical Center — Boston, Massachusetts, United States
• Algemeen Ziekenhuis Middelheim — Antwerp, Belgium
• Hopital Universitaire Erasme — Brussels, Belgium
• Institut Jules Bordet — Brussels (Bruxelles), Belgium
• Cliniques Universitaires Saint-Luc — Brussels (Bruxelles), Belgium
• Kingston General Hospital — Kingston, Ontario, Canada
• Ottawa Regional Cancer Center - General Division — Ottawa, Ontario, Canada
• Masaryk University Hospital — Brno, Czechia
• Turku University Central Hospital — Turku, Finland
• CHR de Besancon - Hopital Saint-Jacques — Besançon, France
• Klinikum der Universitaet Ulm — Ulm, Germany
• Hellenic Institute for Cancer-Saint Savas Hospital — Athens, Greece
• Athens University-Laikon General Hospital — Athens, Greece
• Metaxa's Memorial Cancer Hospital — Piraeus, Greece
• University of Patras Medical School — Rio Patras, Greece
• Wolfson Medical Center — Holon, Israel
• Hadassah University Hospital — Jerusalem, Israel
• Chaim Sheba Medical Center — Ramat Gan, Israel
• National Cancer Institute - Bratislava — Bratislava, Slovakia
• St. Elizabeth Cancer Institute Hospital — Bratislava, Slovakia
• Ospedale San Giovanni — Bellinzona, Switzerland
• Centre Hospitalier Universitaire Vaudois — Lausanne, Switzerland
• Universitaetsspital — Zurich, Switzerland
• Ibn-i Sina Hospital, Ankara Univeristy — Ankara, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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