Antibiotic Therapy With or Without G-CSF in Treating Children With Neutropenia and Fever Caused by Chemotherapy
Completed · Phase 3
Conditions studied: Fever, Sweats, and Hot Flashes, Neutropenia, Unspecified Childhood Solid Tumor, Protocol Specific
In brief
RATIONALE: Antibiotics may decrease the side effects of neutropenia and fever caused by chemotherapy. Colony-stimulating factors such as G-CSF may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's immune system recover from the side effects of chemotherapy. It is not yet known whether antibiotic therapy plus G-CSF is more effective than antibiotic therapy alone for treating side effects caused by chemotherapy. PURPOSE: Randomized phase III trial to compare the effectiveness of antibiotic therapy with or without G-CSF in treating children who have neutropenia and fever that are caused by chemotherapy.
Key facts
- Study ID
- NCT00003739
- Run by
- Children's Oncology Group
- People needed
- 67
- Starts
- 1999-03-01
- Expected to finish
- 2006-09-01
- Last updated by the study team
- 2014-02-14
Who can join
Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of South Alabama Medical Center — Mobile, Alabama, United States
- Phoenix Children's Hospital — Phoenix, Arizona, United States
- Arizona Cancer Center — Tucson, Arizona, United States
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Southern California Permanente Medical Group — Downey, California, United States
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- Loma Linda University Medical Center — Loma Linda, California, United States
- Jonathan Jaques Children's Cancer Center — Long Beach, California, United States
- Children's Hospital Los Angeles — Los Angeles, California, United States
- Cedars-Sinai Medical Center — Los Angeles, California, United States
- Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
- Children's Hospital Central California — Madera, California, United States
- Children's Hospital of Oakland — Oakland, California, United States
- Chao Family Comprehensive Cancer Center — Orange, California, United States
- Children's Hospital of Orange County — Orange, California, United States
- Lucile Packard Children's Hospital at Stanford — Palo Alto, California, United States
- Sutter Cancer Center — Sacramento, California, United States
- University of California Davis Medical Center — Sacramento, California, United States
- Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego — San Diego, California, United States
- Children's Hospital San Diego — San Diego, California, United States
- Kaiser Permanente Medical Center - San Francisco Geary Campus — San Francisco, California, United States
- UCSF Comprehensive Cancer Center — San Francisco, California, United States
- Santa Barbara Cottage Hospital — Santa Barbara, California, United States
- University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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