Carboplatin Plus Paclitaxel With or Without Continued Low-Dose Paclitaxel in Treating Patients With Early-Stage Ovarian Cancer

Completed · Phase 3

Conditions studied: Ovarian Cancer

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known whether receiving combined carboplatin and paclitaxel plus continued low-dose paclitaxel is more effective than carboplatin and paclitaxel alone for early-stage ovarian cancer. PURPOSE: This randomized phase III trial is studying carboplatin and paclitaxel alone too see how well they work compared to carboplatin and paclitaxel together with continued low-dose paclitaxel in treating patients with early-stage ovarian cancer.

Key facts

Study ID

NCT00003644

Run by

Gynecologic Oncology Group

People needed

571

Starts

1998-10-01

Last updated by the study team

2019-06-04

Who can join

Age: any, up to 120. Sex: female. Healthy volunteers: not accepted.

Where it is running

• Banner Thunderbird Medical Center — Glendale, Arizona, United States
• Banner Good Samaritan Medical Center — Phoenix, Arizona, United States
• CCOP - Western Regional, Arizona — Phoenix, Arizona, United States
• Highlands Oncology Group - Fayetteville — Fayetteville, Arkansas, United States
• Washington Regional Medical Center — Fayetteville, Arkansas, United States
• Alta Bates Comprehensive Cancer Center — Berkeley, California, United States
• Peninsula Medical Center — Burlingame, California, United States
• Marin Cancer Institute at Marin General Hospital — Greenbrae, California, United States
• Sutter Health - Western Division Cancer Research Group — Greenbrae, California, United States
• Todd Cancer Institute at Long Beach Memorial Medical Center — Long Beach, California, United States
• Kaiser Permanente Medical Center - Los Angeles — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center at UCLA — Los Angeles, California, United States
• Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center — Orange, California, United States
• University of California Davis Cancer Center — Sacramento, California, United States
• California Pacific Medical Center - California Campus — San Francisco, California, United States
• Torrance Memorial Medical Center — Torrance, California, United States
• Colorado Gynecologic Oncology Group P.C. — Aurora, Colorado, United States
• North Colorado Medical Center — Greeley, Colorado, United States
• McKee Medical Center — Loveland, Colorado, United States
• Helen and Harry Gray Cancer Center at Hartford Hospital — Hartford, Connecticut, United States
• CCOP - Christiana Care Health Services — Newark, Delaware, United States
• University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States
• Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
• H. Lee Moffitt Cancer Center and Research Institute at University of South Florida — Tampa, Florida, United States
• University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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