Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia

Completed · Phase 1/Phase 2

Conditions studied: Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic Syndromes, Thrombocytopenia

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. Isotretinoin may help cancer cells develop into normal white blood cells. PURPOSE: Phase I/II trial of topotecan, fludarabine, cytarabine, and filgrastim followed by peripheral stem cell transplantation or isotretinoin in treating patients who have acute myeloid leukemia, myelodysplastic syndrome, or recurrent or refractory acute lymphocytic leukemia.

Key facts

Study ID

NCT00003619

Run by

Drexel University College of Medicine

Starts

1998-02-01

Expected to finish

2004-04-01

Last updated by the study team

2013-06-26

Who can join

Age: 19 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Medical College of Pennsylvania Hospital — Philadelphia, Pennsylvania, United States
• Medical College of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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