Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer

Completed · Phase 3

Conditions studied: Anal Cancer

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug or combining radiation therapy with chemotherapy may kill more tumor cells. It is not yet known whether fluorouracil and mitomycin plus radiation therapy is more effective than fluorouracil and cisplatin plus radiation therapy for anal cancer. PURPOSE: This randomized phase III trial is studying fluorouracil and mitomycin plus radiation therapy to see how well it works compared to fluorouracil and cisplatin plus radiation therapy in treating patients with stage II or stage III anal cancer.

Key facts

Study ID

NCT00003596

Run by

Radiation Therapy Oncology Group

People needed

682

Starts

1998-10-01

Expected to finish

2016-12-01

Last updated by the study team

2017-01-04

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Mobile Infirmary Medical Center — Mobile, Alabama, United States
• Alaska Regional Hospital — Anchorage, Alaska, United States
• Providence Alaska Medical Center — Anchorage, Alaska, United States
• Foundation for Cancer Research and Education — Phoenix, Arizona, United States
• CCOP - Mayo Clinic Scottsdale Oncology Program — Scottsdale, Arizona, United States
• Hembree Mercy Cancer Center at St. Edward Mercy Medical Center — Fort Smith, Arkansas, United States
• Alta Bates Comprehensive Cancer Center — Berkeley, California, United States
• Providence Saint Joseph Medical Center - Burbank — Burbank, California, United States
• Mills-Peninsula Health Services — Burlingame, California, United States
• Mount Diablo Regional Cancer Center — Concord, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• California Cancer Center - Woodward Park Office — Fresno, California, United States
• Marin Cancer Institute at Marin General Hospital — Greenbrae, California, United States
• Sutter Health Western Division Cancer Research Group — Greenbrae, California, United States
• Saint Rose Hospital — Hayward, California, United States
• Valley Memorial Hospital — Livermore, California, United States
• Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• Providence Holy Cross Cancer Center — Mission Hills, California, United States
• Memorial Medical Center Cancer Services — Modesto, California, United States
• Leavey Cancer Center at Northridge Hospital Medical Center — Northridge, California, United States
• Highland General Hospital — Oakland, California, United States
• CCOP - Bay Area Tumor Institute — Oakland, California, United States
• Summit Medical Center — Oakland, California, United States
• Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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