Methotrexate Compared With Paclitaxel in Treating Patients With Advanced Head and Neck Cancer
Completed · Phase 3
Conditions studied: Head and Neck Cancer
In brief
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether methotrexate or paclitaxel is more effective in treating patients with advanced head and neck cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of methotrexate with that of paclitaxel in treating patients who have advanced head and neck cancer that cannot be treated with cisplatin.
Key facts
- Study ID
- NCT00003592
- Run by
- Eastern Cooperative Oncology Group
- People needed
- 230
- Starts
- 1999-04-22
- Expected to finish
- 2004-03-02
- Last updated by the study team
- 2023-06-22
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Emory University Hospital - Atlanta — Atlanta, Georgia, United States
- Veterans Affairs Medical Center - Atlanta (Decatur) — Decatur, Georgia, United States
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University — Chicago, Illinois, United States
- Veterans Affairs Medical Center - Chicago (Lakeside) — Chicago, Illinois, United States
- CCOP - Illinois Oncology Research Association — Peoria, Illinois, United States
- CCOP - Carle Cancer Center — Urbana, Illinois, United States
- CCOP - Kalamazoo — Kalamazoo, Michigan, United States
- CCOP - Metro-Minnesota — Saint Louis Park, Minnesota, United States
- CCOP - Missouri Valley Cancer Consortium — Omaha, Nebraska, United States
- Veterans Affairs Medical Center - East Orange — East Orange, New Jersey, United States
- University of Rochester Cancer Center — Rochester, New York, United States
- Albert Einstein Comprehensive Cancer Center — The Bronx, New York, United States
- Ireland Cancer Center — Cleveland, Ohio, United States
- CCOP - Toledo Community Hospital Oncology Program — Toledo, Ohio, United States
- Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
- Veterans Affairs Medical Center - Nashville — Nashville, Tennessee, United States
- Vanderbilt Cancer Center — Nashville, Tennessee, United States
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States
- Veterans Affairs Medical Center - Milwaukee (Zablocki) — Milwaukee, Wisconsin, United States
- Pretoria Academic Hospital — Pretoria, South Africa
Full record on ClinicalTrials.gov
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