Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma
Completed · Phase 3
Conditions studied: Lymphoma
In brief
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining more than one drug with radiation therapy may kill more cancer cells. It is not yet known which combination chemotherapy regimen is most effective in treating Hodgkin's lymphoma. PURPOSE: This randomized phase III trial is studying two different combination chemotherapy regimens and comparing how well they work, with or without radiation therapy, in treating patients with Hodgkin's lymphoma.
Key facts
- Study ID
- NCT00003389
- Run by
- Eastern Cooperative Oncology Group
- People needed
- 854
- Starts
- 1999-06-17
- Expected to finish
- 2016-05-01
- Last updated by the study team
- 2023-06-29
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically proven previously untreated classical Hodgkin's lymphoma
- The following stages are eligible:
- Locally extensive: Stage I-IIA/B with massive mediastinal adenopathy
- Advanced: Stage III or IV
- Measurable or evaluable disease
- Age of 16 and over
- ECOG Performance status 0-2
- Disease-free of prior invasive malignancies for >5 years with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix
- White blood cell (WBC) at least 4,000/mm³, (unless documented bone marrow involvement)
- Platelet count at least 100,000/mm³ (unless documented bone marrow involvement)
- Bilirubin no greater than 5.0 mg/dL
- Creatinine no greater than 2.0 mg/dL
- Ejection fraction determination recommended if over age 50 and/or have a history of cardiac disease
- Fertile patients must use effective contraception
- Prior corticosteroids allowed
- Prior surgery allowed
You may not qualify if…
- Pregnant or nursing
- Prior radiotherapy
- Prior chemotherapy
- Human immunodeficiency virus (HIV) positive
Where it is running
- CCOP - Western Regional, Arizona — Phoenix, Arizona, United States
- St. Joseph's Hospital and Medical Center — Phoenix, Arizona, United States
- Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
- Alta Bates Comprehensive Cancer Center — Berkeley, California, United States
- Peninsula Medical Center — Burlingame, California, United States
- Eden Medical Center — Castro Valley, California, United States
- Mount Diablo Regional Cancer Center — Concord, California, United States
- North Bay Cancer Center — Fairfield, California, United States
- Kaiser Permanente - Fremont — Fremont, California, United States
- Marin Cancer Institute at Marin General Hospital — Greenbrae, California, United States
- Sutter Health - Western Division Cancer Research Group — Greenbrae, California, United States
- Kaiser Permanente Medical Center - Hayward — Hayward, California, United States
- Saint Rose Hospital — Hayward, California, United States
- Moores UCSD Cancer Center — La Jolla, California, United States
- Memorial Medical Center Cancer Services — Modesto, California, United States
- Highland General Hospital at St. George's University School of Medicine — Oakland, California, United States
- Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Kaiser Permanente Medical Center - Oakland — Oakland, California, United States
- Valley Care Medical Center — Pleasanton, California, United States
- Kaiser Permanente Medical Center - Redwood City — Redwood City, California, United States
- Kaiser Permanente Medical Center - Richmond — Richmond, California, United States
- Kaiser Permanente Medical Center - Roseville — Roseville, California, United States
- Sutter Cancer Center at Roseville Medical Center — Roseville, California, United States
- Mobile Infirmary Medical Center — Mobile, Alabama, United States
Full record on ClinicalTrials.gov
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