Radiation Therapy, Paclitaxel, and Cisplatin in Treating Patients With Cancer of the Cervix

Completed · Phase 1

Conditions studied: Cervical Cancer

In brief

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Paclitaxel and cisplatin may increase the effectiveness of radiation therapy by making the tumor cells more sensitive to the radiation. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of paclitaxel when given with radiation therapy and cisplatin and to see how well they work in treating patients with cancer of the cervix that has spread to the lymph nodes in the pelvis and abdomen.

Key facts

Study ID

NCT00003377

Run by

Gynecologic Oncology Group

People needed

29

Starts

1999-11-01

Expected to finish

2009-07-01

Last updated by the study team

2013-02-04

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

Where it is running

• University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
• Cancer Institute of New Jersey at the Cooper University Hospital - Voorhees — Camden, New Jersey, United States
• Comprehensive Cancer Center at Wake Forest University — Winston-Salem, North Carolina, United States
• MetroHealth's Cancer Care Center at MetroHealth Medical Center — Cleveland, Ohio, United States
• Cleveland Clinic Cancer Center at Fairview Hospital — Cleveland, Ohio, United States
• Cleveland Clinic Taussig Cancer Center — Cleveland, Ohio, United States
• Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University — Columbus, Ohio, United States
• Riverside Methodist Hospital Cancer Care — Columbus, Ohio, United States
• Oklahoma University Medical Center — Oklahoma City, Oklahoma, United States
• Cancer Care Associates - Midtown Tulsa — Tulsa, Oklahoma, United States
• Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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