Two-Drug Combination Chemotherapy Compared With Four-Drug Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium

Completed · Phase 3

Conditions studied: Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral Cancer

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known if four-drug combination chemotherapy is more effective than two-drug combination chemotherapy in treating advanced cancer of the urothelium. PURPOSE: Randomized phase III trial to compare the effectiveness of four-drug combination chemotherapy with that of two-drug combination chemotherapy in treating patients who have advanced cancer of the urothelium.

Key facts

Study ID

NCT00003376

Run by

Eastern Cooperative Oncology Group

People needed

330

Starts

1998-12-03

Last updated by the study team

2023-06-22

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Veterans Affairs Medical Center - Birmingham — Birmingham, Alabama, United States
• University of California San Diego Cancer Center — La Jolla, California, United States
• UCSF Cancer Center and Cancer Research Institute — San Francisco, California, United States
• Veterans Affairs Medical Center - San Francisco — San Francisco, California, United States
• CCOP - Christiana Care Health Services — Wilmington, Delaware, United States
• Lombardi Cancer Center, Georgetown University — Washington D.C., District of Columbia, United States
• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
• CCOP - Mount Sinai Medical Center — Miami Beach, Florida, United States
• University of Illinois at Chicago Health Sciences Center — Chicago, Illinois, United States
• Veterans Affairs Medical Center - Chicago (Westside Hospital) — Chicago, Illinois, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• Veterans Affairs Medical Center - Togus — Togus, Maine, United States
• Marlene & Stewart Greenebaum Cancer Center, University of Maryland — Baltimore, Maryland, United States
• Veterans Affairs Medical Center - Baltimore — Baltimore, Maryland, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• University of Massachusetts Memorial Medical Center — Worcester, Massachusetts, United States
• Veterans Affairs Medical Center - Minneapolis — Minneapolis, Minnesota, United States
• University of Minnesota Cancer Center — Minneapolis, Minnesota, United States
• Veterans Affairs Medical Center - Columbia (Truman Memorial) — Columbia, Missouri, United States
• Ellis Fischel Cancer Center - Columbia — Columbia, Missouri, United States
• Barnes-Jewish Hospital — St Louis, Missouri, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• CCOP - Southern Nevada Cancer Research Foundation — Las Vegas, Nevada, United States
• Norris Cotton Cancer Center — Lebanon, New Hampshire, United States

Full record on ClinicalTrials.gov

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