Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases

Completed · Not applicable

Conditions studied: Metastatic Cancer

In brief

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells in a single high dose. Combining radiation therapy with surgery may be a more effective treatment for brain metastases. PURPOSE: Clinical trial to study the effectiveness of radiation therapy with or without surgery in treating patients who have brain metastases.

Key facts

Study ID

NCT00003324

Run by

Jonsson Comprehensive Cancer Center

People needed

61

Starts

1997-12-01

Last updated by the study team

2020-08-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Biopsy, CT scan, or MRI proven cerebral metastases with known current or previous systemic malignancy OR
• Biopsy proven cerebral metastases other than from small cell lung cancer or lymphoma
• Refused whole brain radiation therapy OR
• Received prior whole brain radiation therapy and ineligible for other relapse protocols
• 18 and over
• Karnofsky 60-100%
• Life expectancy:At least 3 months
• Concurrent steroids allowed

You may not qualify if…

• more than four cerebral metastases on MRI scan and suitable for focal treatment with surgery and/or stereotactic radiotherapy with a linear accelerator
• more than 2 weeks since prior focal radiation
• more than 2 weeks since prior focal surgery

Where it is running

• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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